Pyrroles

1 – 12 of 12 results

ITX3, MedChemExpress

MedChemExpress ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	371.45
Color	Light Green
Physical Form	Solid
Chemical Name or Material	ITX3
Grade	Research
SMILES	O=C(/C1=C\C2=C(C)N(C(C)=C2)C3=CC=CC=C3)N4C(S1)=NC5=CC=CC=C45
Percent Purity	98.01%
CAS	347323-96-0
Solubility Information	DMSO : 2 mg/mL (5.38 mM; ultrasonic and warming and heat to 80°C)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₁₇N₃OS
Formula Weight	371.45

Mebhydrolin, MedChemExpress

MedChemExpress Mebhydrolin is a specific histamine H1 receptor antagonist.

Pricing and Availability

MedChemExpress BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	641.8
Color	Off-White
Physical Form	Solid
Chemical Name or Material	BQ-788
Grade	Research
SMILES	CCCC[C@H](C(O)=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O
For Use With (Application)	Metabolism-sugar/lipid metabolism
Percent Purity	98.28%
CAS	173326-37-9
Solubility Information	DMSO : 170 mg/mL (264.88 mM; ultrasonic and warming and heat to 60°C)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₄H₅₁N₅O₇
Formula Weight	641.8

BMS-986158, MedChemExpress

MedChemExpress BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	495.62
Color	White
Physical Form	Solid
Chemical Name or Material	BMS-986158
Grade	Research
SMILES	OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.22%
CAS	1800340-40-2
Solubility Information	DMSO : 50 mg/mL (100.88 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₀H₃₃N₅O₂
Formula Weight	495.62

Mebhydrolin napadisylate, MedChemExpress

MedChemExpress Mebhydrolin napadisylate is a specific histamine H1 receptor antagonist.

Pricing and Availability

Eniporide hydrochloride, MedChemExpress

MedChemExpress Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	356.83
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Eniporide hydrochloride
Grade	Research
SMILES	CS(=O)(C1=C(N2C=CC=C2)C=C(C)C(C(NC(N)=N)=O)=C1)=O.[H]Cl
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.05%
CAS	211813-86-4
Solubility Information	DMSO : 55 mg/mL (154.14 mM; Need ultrasonic) ∣H2O : 4.17 mg/mL (11.69 mM; ultrasonic and warming and heat to 60°C)
Synonym	EMD-96785 hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₄H₁₇ClN₄O₃S
Formula Weight	356.83

PhiKan 083 hydrochloride, MedChemExpress

MedChemExpress PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells.

Pricing and Availability

Osimertinib mesylate, MedChemExpress

MedChemExpress Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	595.71
Color	Yellow
Physical Form	Powder
Chemical Name or Material	Osimertinib mesylate
Grade	Research
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.74%
CAS	1421373-66-1
Solubility Information	DMSO : 13.89 mg/mL (23.32 mM; ultrasonic and warming and heat to 80°C)
Health Hazard 1	H315∣H319∣H335
Synonym	AZD-9291 mesylate Mereletinib mesylate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₉H₃₇N₇O₅S
Formula Weight	595.71

Ribociclib succinate, MedChemExpress

MedChemExpress Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	552.63
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Ribociclib succinate
Grade	Research
SMILES	O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5.OC(CCC(O)=O)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.01%
CAS	1374639-75-4
Solubility Information	DMSO : 41.67 mg/mL (75.40 mM; Need ultrasonic) ∣H2O : 4.17 mg/mL (7.55 mM; ultrasonic and warming and heat to 60°C)
Synonym	LEE011 succinate
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₇H₃₆N₈O₅
Formula Weight	552.63

HLCL-61 hydrochloride, MedChemExpress

MedChemExpress HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	380.91
Color	White
Physical Form	Solid
Chemical Name or Material	HLCL-61 hydrochloride
Grade	Research
SMILES	[H]Cl.COC1=CC=CC=C1CNCC2=CC3=C(C=C2)N(CC)C4=C3C=CC=C4
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.95%
CAS	1158279-20-9
Solubility Information	DMSO : 50 mg/mL (131.26 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₃H₂₅ClN₂O
Formula Weight	380.91

(E)-SIS3, MedChemExpress

MedChemExpress (E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	489.99
Color	Deep Yellow
Physical Form	Solid
Chemical Name or Material	(E)-SIS3
Grade	Research
SMILES	[H]Cl.O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC.[E]
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	521984-48-5
Solubility Information	DMSO : 125 mg/mL (255.11 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₈H₂₈ClN₃O₃
Formula Weight	489.99

Ulixertinib hydrochloride, MedChemExpress

MedChemExpress Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	469.79
Color	White
Physical Form	Solid
Chemical Name or Material	Ulixertinib hydrochloride
Grade	Research
SMILES	O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[C@@H](C3=CC=CC(Cl)=C3)CO.[H]Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.81%
CAS	1956366-10-1
Solubility Information	DMSO : 100 mg/mL (212.86 mM; Need ultrasonic) ∣H2O : 0.1 mg/mL (0.21 mM; ultrasonic and warming and heat to 80°C)
Synonym	BVD-523 hydrochlorideVRT752271 hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₁H₂₃Cl₃N₄O₂
Formula Weight	469.79

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