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Ulixertinib hydrochloride, MedChemExpress

Product Code. 16466848
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Product Code. 16466848 Supplier Medchem Express Supplier No. HY15816A

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Description

MedChemExpress Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

Specifications

Chemical Name or Material Ulixertinib hydrochloride
CAS 1956366-10-1
Color White
Purity Grade Notes Research
Molecular Formula C21H23Cl3N4O2
Quantity 10 mg
Synonym BVD-523 hydrochlorideVRT752271 hydrochloride
Solubility Information DMSO : 100 mg/mL (212.86 mM; Need ultrasonic) ∣H2O : 0.1 mg/mL (0.21 mM; ultrasonic and warming and heat to 80°C)
SMILES O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[C@@H](C3=CC=CC(Cl)=C3)CO.[H]Cl
Molecular Weight (g/mol) 469.79
Formula Weight 469.79
Percent Purity 99.81%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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