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Osimertinib mesylate, MedChemExpress

Product Code. 16491196
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Product Code. 16491196 Supplier Medchem Express Supplier No. HY15772A

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Description

MedChemExpress Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

Specifications

Chemical Name or Material Osimertinib mesylate
CAS 1421373-66-1
Color Yellow
Purity Grade Notes Research
Molecular Formula C29H37N7O5S
Quantity 200 mg
Synonym AZD-9291 mesylate Mereletinib mesylate
Solubility Information DMSO : 13.89 mg/mL (23.32 mM; ultrasonic and warming and heat to 80°C)
SMILES C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
Molecular Weight (g/mol) 595.71
Formula Weight 595.71
Percent Purity 98.74%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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