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(E)-SIS3, MedChemExpress

Product Code. 16495478
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Product Code. 16495478 Supplier Medchem Express Supplier No. HY13013

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Description

MedChemExpress (E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

(E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

Specifications

Chemical Name or Material (E)-SIS3
CAS 521984-48-5
Color Deep Yellow
Purity Grade Notes Research
Molecular Formula C28H28ClN3O3
Quantity 10 mg
Solubility Information DMSO : 125 mg/mL (255.11 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES [H]Cl.O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC.[E]
Molecular Weight (g/mol) 489.99
Formula Weight 489.99
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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