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Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1 – 15 of 107 results
1

Tocris Bioscience™ Ibrutinib
GREENER_CHOICE

Potent and selective BTK inhibitor (IC50= 0.5 nM)

CAS 936563-96-1
Purity 98%
Chemical Name or Material 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Recommended Storage Store at -20°C
Synonym Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase
Molecular Formula C25H24N6O2
Formula Weight 440.5
2

Tocris Bioscience™ PCI 29732
GREENER_CHOICE

Potent BTK inhibitor

Inhibitors PCI 29732
Product Type PCI 29732
Molecular Weight (g/mol) 371.44
Purity >99%
3

Tocris Bioscience™ UNC 2881
GREENER_CHOICE

Potent Mer kinase inhibitor

CAS 1493764-08-1
Purity 98%
Chemical Name or Material 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
Recommended Storage Store at 4°C
Molecular Formula C25H33N7O2
Formula Weight 463.58
4

Tocris Bioscience™ BAY 826
GREENER_CHOICE

Potent Tie2 inhibitor

CAS 1448316-08-2
Purity 98%
Chemical Name or Material [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Recommended Storage Store at -20°C
Molecular Formula C26H19F5N6OS
Formula Weight 558.53
5

Tocris Bioscience™ CGI 1746
GREENER_CHOICE

Potent, reversible BTK inhibitor

Target Brutons Tyrosine Kinase (BTK) Inhibitors
CAS 910232-84-7
Purity 0.97
Chemical Name or Material N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
Recommended Storage Store at -20°C
Molecular Formula C34H37N5O4
6

Tocris Bioscience™ DDR1-IN-1 dihydrochloride
GREENER_CHOICE

Selective DDR1 inhibitor

Inhibitors DDR1-IN-1 dihydrochloride
CAS 1780303-76-5
Product Type DDR1-IN-1 dihydrochloride
Molecular Weight (g/mol) 625.51
Purity >98%
7

Tocris Bioscience™ AZM 475271
GREENER_CHOICE

CAS: 476159-98-5 Molecular Formula: C23H27ClN4O3

CAS 476159-98-5
Molecular Formula C23H27ClN4O3
8

Tocris Bioscience™ ZAP 180013
GREENER_CHOICE

Zap70 inhibitor; inhibits interaction with ITAMs

CAS 873080-25-2
Purity 98%
Chemical Name or Material 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
Recommended Storage Store at -20°C
Molecular Formula C19H17Cl2N3O4S
9

Tocris Bioscience™ TCS 359
GREENER_CHOICE

CAS: 301305-73-7 Molecular Formula: C18H20N2O4S

CAS 301305-73-7
Molecular Formula C18H20N2O4S
10

Tocris Bioscience™ SPP 86
GREENER_CHOICE

Potent RET inhibitor

Product Type SPP 86
Molecular Weight (g/mol) 277.32
Purity >98%
11

Tocris Bioscience™ 7,8-Dihydroxyflavone
GREENER_CHOICE

CAS: 38183-03-8 Molecular Formula: C15H10O4

CAS 38183-03-8
Molecular Formula C15H10O4
12

Tocris Bioscience™ LFM-A13
GREENER_CHOICE

CAS: 62004-35-7 Molecular Formula: C11H8Br2N2O2

CAS 62004-35-7
Molecular Formula C11H8Br2N2O2
13

Tocris Bioscience™ TC JL 37
GREENER_CHOICE

Potent TYK2 inhibitor

CAS 1258294-34-6
Chemical Name or Material 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
Recommended Storage Store at 4°C
Molecular Formula C17H11ClF2N4O2
Formula Weight Observed MW: 376.74
Assay Percent Range >98%
14

Tocris Bioscience™ AZ 191
GREENER_CHOICE

Potent DYRK1B inhibitor

CAS 1594092-37-1
Product Type Bioactive Small Molecule
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Purity >98%
Physical Form Solid
Chemical Name or Material AZ 191
Recommended Storage Store at -20°C
Synonym N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
Molecular Formula C24H27N7O
Formula Weight 429.52
15

Tocris Bioscience™ GSK 143
GREENER_CHOICE

Syk inhibitor

Product Type Inhibitor
Purity 98%
Recommended Storage Store at -20°C
Molecular Formula C17H22N6O2.2HCl
Formula Weight 415.32