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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 184 results
1

PCI-34051, MedChemExpress

MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 296.32
Color Off-White
Physical Form Solid
Chemical Name or Material PCI-34051
Grade Research
SMILES COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
For Use With (Application) Cancer-programmed cell death
Percent Purity 97.28%
CAS 950762-95-5
Solubility Information DMSO : ≥ 30 mg/mL (101.24 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H16N2O3
Formula Weight 296.32
2

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

ENCOMPASS_PREFERRED
3

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 269.73
Color Earth Yellow
Physical Form Solid
Chemical Name or Material Oncrasin-1
Grade Research
SMILES O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.28%
CAS 75629-57-1
Solubility Information DMSO : ≥ 43 mg/mL (159.42 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C16H12ClNO
Formula Weight 269.73
4

Apyramide, MedChemExpress

MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 490.93
Color White
Physical Form Solid
Chemical Name or Material Apyramide
Grade Research
SMILES O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.06%
CAS 68483-33-0
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H23ClN2O5
Formula Weight 490.93
5

Staurosporine, MedChemExpress

MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 466.53
Color Light Yellow
Physical Form Powder
Chemical Name or Material Staurosporine
Grade Research
SMILES O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 62996-74-1
Solubility Information DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic)
Synonym Antibiotic AM-2282 STS AM-2282
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H26N4O3
Formula Weight 466.53
6

Metergoline, MedChemExpress

MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 403.52
Color White
Physical Form Solid
Chemical Name or Material Metergoline
Grade Research
SMILES O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.62%
CAS 17692-51-2
Solubility Information DMSO : 125 mg/mL (309.77 mM; Need ultrasonic)
Health Hazard 1 H302∣H312∣H332
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H29N3O2
Formula Weight 403.52
7

Acrizanib, MedChemExpress

MedChemExpress Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 445.4
Color White
Physical Form Solid
Chemical Name or Material Acrizanib
Grade Research
SMILES O=C(N1C2=CC=C(OC3=NC=NC(CNC)=C3)C=C2C=C1)NC4=NN(C)C(C(F)(F)F)=C4
Percent Purity 98.23%
CAS 1229453-99-9
Solubility Information DMSO : 41.67 mg/mL (93.56 mM; Need ultrasonic)
Synonym LHA510
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H18F3N7O2
Formula Weight 445.4
8

Ribociclib, MedChemExpress

MedChemExpress Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 434.54
Color Light Yellow
Physical Form Powder
Chemical Name or Material Ribociclib
Grade Research
SMILES O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(N=C4)=CC=C4N5CCNCC5
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.52%
CAS 1211441-98-3
Solubility Information DMSO : 20 mg/mL (46.03 mM; Need ultrasonic)
Synonym LEE011
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H30N8O
Formula Weight 434.54
9

CAY10650, MedChemExpress

MedChemExpress CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 471.5
Color Off-White
Physical Form Solid
Chemical Name or Material CAY10650
Grade Research
SMILES O=C(CN1C(C=CC(C(O)=O)=C2)=C2C(C(C(C)C)=O)=C1)COC(C=C3)=CC=C3OC4=CC=CC=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.0%
CAS 1233706-88-1
Solubility Information DMSO : ≥ 43 mg/mL (91.20 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H25NO6
Formula Weight 471.5
10

GSK376501A, MedChemExpress

MedChemExpress GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

ENCOMPASS_PREFERRED
11

YM-90709, MedChemExpress

MedChemExpress YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 359.42
Color Orange
Physical Form Solid
Chemical Name or Material YM-90709
Grade Research
SMILES CC(CC1=CC(OC)=C(OC)C=C12)(C)N3C2=CC4=NC5=CC=CC=C5N=C43
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.52%
CAS 163769-88-8
Solubility Information DMSO : 62.5 mg/mL (173.89 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H21N3O2
Formula Weight 359.42
12

FMK, MedChemExpress

MedChemExpress FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 342.37
Color Light Yellow
Physical Form Solid
Chemical Name or Material FMK
Grade Research
SMILES FCC(C1=C(C2=C(N=CN=C2N1CCCO)N)C3=CC=C(C=C3)C)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.05%
CAS 821794-92-7
Solubility Information DMSO : 100 mg/mL (292.08 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C18H19FN4O2
Formula Weight 342.37
13

ML-098, MedChemExpress

MedChemExpress ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 309.36
Color White
Physical Form Solid
Chemical Name or Material ML-098
Grade Research
SMILES O=C(C1=CN(CCOC2=CC(C)=CC=C2C)C3=C1C=CC=C3)O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.89%
CAS 878978-76-8
Solubility Information DMSO : ≥ 29 mg/mL (93.74 mM)
Synonym CID-7345532
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H19NO3
Formula Weight 309.36
14

Amcasertib, MedChemExpress

MedChemExpress Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 539.69
Color Yellow
Physical Form Solid
Chemical Name or Material Amcasertib
Grade Research
SMILES O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.15%
CAS 1129403-56-0
Solubility Information DMSO : ≥ 30 mg/mL (55.59 mM)
Synonym BBI503
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C31H33N5O2S
Formula Weight 539.69
15

(S)-Ketorolac, MedChemExpress

MedChemExpress (S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 255.27
Color Off-White
Physical Form Solid
Chemical Name or Material (S)-Ketorolac
Grade Research
SMILES O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@@H]3C(O)=O
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.62%
CAS 66635-92-5
Solubility Information DMSO : 200 mg/mL (783.48 mM; Need ultrasonic)
Synonym (-)-Ketorolac
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C15H13NO3
Formula Weight 255.27