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CAS RN 1420477-60-6

CAS RN 1420477-60-6

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1

Acalabrutinib, TRC

CAS: 1420477-60-6 Molecular Formula: C26H23N7O2 Molecular Weight (g/mol): 465.51 Synonym: 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide,ACP 196 IUPAC Name: 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide SMILES: CC#CC(=O)N1CCC[C@H]1c2nc(c3ccc(cc3)C(=O)Nc4ccccn4)c5c(N)nccn25

CAS 1420477-60-6
Molecular Weight (g/mol) 465.51
SMILES CC#CC(=O)N1CCC[C@H]1c2nc(c3ccc(cc3)C(=O)Nc4ccccn4)c5c(N)nccn25
Synonym 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide,ACP 196
IUPAC Name 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
Molecular Formula C26H23N7O2
2

Acalabrutinib, MedChemExpress

MedChemExpress Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 465.51
Color Off-White
Physical Form Solid
Chemical Name or Material Acalabrutinib
Grade Research
SMILES O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 1420477-60-6
Solubility Information DMSO : 250 mg/mL (537.05 mM; Need ultrasonic)
Synonym ACP-196
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H23N7O2
Formula Weight 465.51