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CAS RN 1254053-43-4

CAS RN 1254053-43-4

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1

Tocris Bioscience™ Gilteritinib
GREENER_CHOICE

Potent FLT3 inhibitor; also potently inhibits AXL

Target Flt-3/Flk-2/CD135
CAS 1254053-43-4
Purity 0.98
Chemical Name or Material 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
Recommended Storage Store at -20°C
Molecular Formula C29H44N8O3
2

Gilteritinib, TRC

CAS: 1254053-43-4 Molecular Formula: C29H44N8O3 Molecular Weight (g/mol): 552.71 Synonym: ASP 2215,6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide IUPAC Name: 6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide SMILES: NC(C(N=C1CC)=C(NC(C=C2)=CC(OC)=C2N3CCC(CC3)N4CCN(CC4)C)N=C1NC5CCOCC5)=O

CAS 1254053-43-4
Molecular Weight (g/mol) 552.71
SMILES NC(C(N=C1CC)=C(NC(C=C2)=CC(OC)=C2N3CCC(CC3)N4CCN(CC4)C)N=C1NC5CCOCC5)=O
Synonym ASP 2215,6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
IUPAC Name 6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
Molecular Formula C29H44N8O3
3

Gilteritinib, MedChemExpress

MedChemExpress Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 552.71
Color Light Yellow
Physical Form Solid
Chemical Name or Material Gilteritinib
Grade Research
SMILES NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 97.77%
CAS 1254053-43-4
Solubility Information Ethanol : 100 mg/mL (180.93 mM; ultrasonic and adjust pH to 2 with HCl) ∣DMSO : 2 mg/mL (3.62 mM; Need ultrasonic)
Synonym ASP2215
Purity Grade Notes Research
Recommended Storage 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Shelf Life 4°C, stored under nitrogen∣In solvent : -80°C, 6 months∣-20°C, 1 month (stored under nitrogen)
Molecular Formula C29H44N8O3
Formula Weight 552.71