missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. Tetracycline, MP Biomedicals™

Tetracycline, MP Biomedicals™

Product Code. 11493391 Shop All MP Biomedicals Products
Change view
Click to view available options
Quantity:
25 g
100 g
Unit Size:
100g
25g
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
11493391 25 g 25g
11403401 100 g 100g
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 11493391 Supplier MP Biomedicals Supplier No. 0210301225

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Tetracyline is used as an antibiotic, in tetracycline controlled gene expression systems, and to select tetracyline resistant colonies.

  • Tetracyline inhibits gram-positive, gram-negative and mycoplasma.
  • It is used in tetracycline controlled gene expression systems (gene switches) such as the tet-on and tet-off systems.
  • It is also used to select tetracyline resistant colonies in cell culture.

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 60-54-8
Molecular Formula C22H24N2O8
Molecular Weight (g/mol) 444.44
MDL Number MFCD00151232
InChI Key JYHCQVWYCGHXGP-BPPSBWQWSA-N
Synonym Abramycin, Tetraverine
PubChem CID 54675776
IUPAC Name (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione
SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)C4=C(O)C=CC=C4[C@@]3(C)O)C(=O)[C@]2(O)C(=O)\C(=C(\N)O)C1=O

Specifications

Type Tetracyline Free Base
Physical Form Powder
Absorbance λmax (0.1N HCl) 217 to 220, 268 to 271, 355 to 356 nm
pH 3.0 to 7.0 (saturated soln.)
Melting Point 417°F (Decomposition)
Source Streptomyces spp.
Potency ≥900 μg/mg
Color Yellow
Concentration 10 μg/mL
Quantity 25 g
Assay Percent Range 0.944
Optical Rotation [α]20/D −230 ± 5°, c = 1% in methanol
Solubility Information 50 to 100 mg/mL at 72°F
Formula Weight 444.4
Chemical Name or Material Tetracyline Free Base
Show More Show Less

Safety and Handling

compliance-icons
Product Identifier
  • Tetracycline Free Base
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
 Hazard Statement
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P101-If medical advice is needed, have product container or label at hand.
  • P102-Keep out of reach of children.
  • P103-Read label before use.
  • P264-Wash thoroughly after handling.
  • P270-Do not eat, drink or smoke when using this product.
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
  • P330-Rinse mouth.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Supplemental information
  • MIXTURE LIST-Contains : tetracycline

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use.

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.