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  5. R&D Systems™ SR 95531 hydrobromide

R&D Systems™ SR 95531 hydrobromide

Product Code. 30001219
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Product Code. 30001219 Supplier R&D Systems™ Supplier No. 1262/10
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    219.00 EUR
    206.85 EUR / 10mg
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Description

A Tocris product, part of R&D Systems. Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 104104-50-9
Molecular Formula C15H18BrN3O3

Specifications

Quantity 10 mg
Product Line Tocris
Formula Weight 368.23
Purity >98%
Molecular Weight (g/mol) 368.231
Chemical Name or Material SR 95531 hydrobromide
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