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SOX10 Antibody (SOX10/991), HRP, Novus Biologicals™

Product Code. 18214553 Shop All Bio Techne Products
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Quantity:
100 μL
Unit Size:
100µL
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18214553 100 μL 100µL
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Product Code. 18214553 Supplier Novus Biologicals Supplier No. NBP259621H
  • ONLINE EXCLUSIVE PRICE
    673.00 EUR
    636.30 EUR / 100µL
    Save 36.70 EUR
    5% Off
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Estimated Shipment: 05-08-2026
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Description

Mouse Monoclonal Antibody

SOX10 Monoclonal specifically detects SOX10 in Human, Mouse samples. It is validated for CyTOF, Flow Cytometry, Flow Cytometry (Intracellular Staining), Immunohistochemistry, Immunohistochemistry (Paraffin), Protein Array, Western Blot.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX10
Applications CyTOF, Flow Cytometry, Flow Cytometry (Intracellular Staining), Immunohistochemistry, Immunohistochemistry (Paraffin), Protein Array, Western Blot
Classification Monoclonal
Clone SOX10/991
Conjugate HRP
Dilution Western Blot, Immunohistochemistry-Paraffin
Formulation PBS with No Preservative
Gene Alias MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of
Gene Symbols SOX10
Host Species Mouse
Immunogen Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary) (Uniprot: P56693)
Purification Method Protein A or G purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6663
Test Specificity The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∼55kDa, identified as SOX10. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Target Species Human, Mouse
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2b κ
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For Research Use Only (RUO)

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