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Tocris Bioscience™ Ro 08-2750
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Product Code. 18004852
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Quantity:
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10 mg
50 mg
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10mg
1mg
50mg
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Product Code. 18004852

Brand: Tocris Bioscience™ 2272/50

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Description

Inhibits NGF binding to p75NTR and TrkA

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ∽ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 37854-59-4
Molecular Formula C13H10N4O3

Specifications

Quantity 50 mg
Formula Weight 270.24
Purity >96%
Molecular Weight (g/mol) 270.248
Chemical Name or Material Ro 08-2750
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