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STEMCELL Technologies R848

Product Code. 17117421
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Product Code. 17117421 Supplier STEMCELL Technologies Supplier No. 73782

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Description

Immune modulator; Inhibits TLR7 and TLR8

  • R848 is an imidazoquinoline and agonist of Toll-like receptors (TLRs) 7 and 8
  • It mimics the pathogen-associated molecular patterns that activate immune cells through TLR7 and TLR8, and thereby acts as an immune-response modifier
  • It demonstrates potent anti-tumor and anti-viral properties (IC50 = 4.2 μM; Seganish et al.) which appear to be mediated predominantly through the induction of cytokines, including interferon (IFN)-α and interleukin (IL)-12 due to stimulation of monocytes, macrophages, and dendritic cells (Bernstein et al.; Hattermann et al.; Nian et al.)

Specifications

CAS 144875-48-9
Synonym Resiquimod; S 28463
Quantity 10 mg
Molecular Formula C17H22N4O2
Purity ≥98%
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