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R&D Systems™ Paxilline
Description
Potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM).
Specifications
Specifications
| CAS | 57186-25-1 |
| Quantity | 10 mg |
| Product Line | Tocris |
| Molecular Formula | C27H33NO4 |
| Formula Weight | 435.56 |
| Purity | >98% |
| Molecular Weight (g/mol) | 435.564 |
| Chemical Name or Material | Paxilline |
Product Title
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