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  5. Tocris Bioscience™ MTK 458

Tocris Bioscience™ MTK 458

Product Code. 18044812
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50 mg
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18044812 10 mg 10mg
18004822 50 mg 50mg
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Product Code. 18044812 Supplier Tocris Bioscience™ Supplier No. 7980/10

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Description

PINK1 activator

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 2499962-58-0
Quantity 10 mg
Target PINK1
Molecular Formula C17H15F3N4
Purity 0.98
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