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STEMCELL Technologies Lapatinib​

Product Code. 17130192
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10 mg
Unit Size:
10mg
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Product Code. 17130192 Supplier STEMCELL Technologies Supplier No. 73242

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Description

Tyrosine kinase inhibitor; Inhibits EGFR and HER2

  • Lapatinib is a selective dual inhibitor of epidermal growth factor receptor (EGFR, ERBB1) and human epidermal growth factor receptor 2 (HER2, ERBB2), each with an IC50 of about 10 nM (Rusnak et al.) It binds reversibly, but with a very slow off-rate, to the ATP binding pocket in an inactive-like conformation, thus preventing autophosphorylation
  • Binding is very potent, with Ki values of 3 and 13 nM to EGFR and HER2 respectively (Wood et al.)
  • Induces apoptosis in cells overexpressing EGFR and/or HER2, and inhibits tumor growth in a mouse xenograft model (Xia et al.)

Specifications

CAS 231277-92-2
Synonym GSK 572016; GW 572016; Tyverb; GW2016
Quantity 10 mg
Molecular Formula C29H26ClFN4O4S
Purity ≥98%
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