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STEMCELL Technologies Imatinib (Mesylate)

Product Code. 17140082
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25 mg
Unit Size:
25mg
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17140082 25 mg 25mg
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Product Code. 17140082 Supplier STEMCELL Technologies Supplier No. 72532

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Description

Tyrosine kinase inhibitor; Inhibits ABL, PDGFR, and KIT

  • Imatinib mesylate is a first generation tyrosine kinase inhibitor that selectively targets certain tyrosine kinases, including ABL, platelet-derived growth factor receptor (PDGFR), and KIT (Druker, 2008; Müller)
  • Inhibits proliferation of primary cultured human mesenchymal stem cells, and promotes adipogenic over osteogenic differentiation (Fierro et al.)
  • Induces osteoblast differentiation in cultured osteoblastic cells, and reduces osteoclastogenesis in mouse bone marrow cultures (O'Sullivan et al.)
  • In CML, Imatinib inhibits the oncoprotein BCR-ABL, the product of the Philadelphia chromosome gene fusion (Carroll et al.; Druker et al.), 1996)
  • Inhibits autonomous erythropoiesis in peripheral blood mononuclear cells isolated from patients with polycythemia vera (Oehler et al.)

Specifications

CAS 220127-57-1
Synonym CGP57148B; Gleevec; Glivec; STI-571
Quantity 25 mg
Molecular Formula C29H31N7O · CH4SO3
Purity ≥98%
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