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Tocris Bioscience™ GMB 475
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Product Code. 18769356
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5 mg
Unit Size:
5mg
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Product Code. 18769356 Supplier Tocris Bioscience™ Supplier No. 7265/5

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Description

BCR-ABL1 kinase PROTAC™

GMB 475 is a BCR-ABL1 kinase PROTAC™ Degrader. Induces degradation of BCR-ABL1 and cABL1, inhibits downstream STAT5 signaling and suppresses cell proliferation in chronic myeloid leukemia cells lines. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Specifications

Chemical Name or Material (2 S,4 R)-1-(-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2490599-18-1
Quantity 5 mg
Target Active Degraders
Molecular Formula C43H46F3N7O7S
Purity 0.98
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