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  7. (-)-Cotinine, 98%

(-)-Cotinine, 98%

Product Code. 11312687
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Quantity:
250 mg
1 g
Unit Size:
1g
250mg
Product Code. Quantity unitSize
11312687 250 mg 250mg
11302687 1 g 1g
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Product Code. 11312687

Brand: Thermo Scientific Alfa Aesar L11873.MD

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Description

CAS: 486-56-6 | C10H12N2O | 176.219 g/mol

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 486-56-6
Molecular Formula C10H12N2O
Molecular Weight (g/mol) 176.219
MDL Number MFCD00077696
InChI Key UIKROCXWUNQSPJ-VIFPVBQESA-N
Synonym cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
PubChem CID 854019
ChEBI CHEBI:68641
IUPAC Name (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
SMILES CN1C(CCC1=O)C2=CN=CC=C2

Specifications

Melting Point 34°C to 39°C
Boiling Point 145°C to 147°C (3 mmHg)
Flash Point >110°C (230°F)
Quantity 250 mg
Beilstein 83099
Merck Index 14,2553
Solubility Information Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM),ethanol (50mg/ml,yielding a clear,faint yellow to yellow solution),methanol and chloroform.
Optical Rotation −20° (c=1 in Ethanol)
Formula Weight 176.22
Percent Purity 98%
Chemical Name or Material (-)-Cotinine
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Safety and Handling

compliance-icons
Product Identifier
  • (-)-Cotinine
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H302-Harmful if swallowed.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contains : Cotinine
SDS

RUO – Research Use Only

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