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Thermo Scientific Chemicals Aldosterone, 98%

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Beschreibung

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)
  • It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

  • Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure
  • In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes
  • Aldosterone has been used in combination with salt to induce renal injury in mice
  • It is used to stimulate primary liver sinusoidal endothelial cells
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 52-39-1
Molecular Formula C21H28O5
Molecular Weight (g/mol) 360.45
MDL Number MFCD00051136
InChI Key PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Synonym aldosterone, electrocortin, aldocortin, aldocorten, aldocortene, +-aldosterone, elektrocortin, d-aldosterone, reichstein x, 18-oxocorticosterone
PubChem CID 5839
ChEBI CHEBI:27584
IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O

Spezifikation

CAS Min % 97.5
CAS Max % 100.0
Color White
Loss on Drying 6.0% max. (105°C, 3 hrs)
Infrared Spectrum Authentic
Assay Percent Range 98%
Packaging Glass bottle
Quantity 5 mg
Beilstein 08, IV, 3491
Merck Index 15, 218
Specific Rotation +150° to +162° (20°C, 589nm) (c=0.1, CHCl3)
Formula Weight 360.45
Percent Purity ≥97.5% (HPLC)
Physical Form Crystalline Powder
Chemical Name or Material Aldosterone, 98%
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