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  6. 2-Cyanoethyl diisopropylchlorophosphoramidite, 95%

2-Cyanoethyl diisopropylchlorophosphoramidite, 95%

Product Code. 11399415
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5 g
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Product Code. Quantity unitSize
11399415 1 g 1g
11309425 5 g 5g
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Product Code. 11399415

Brand: Thermo Scientific Alfa Aesar L18575.03

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Description

CAS: 89992-70-1 | C9H18ClN2OP | 236.68 g/mol

2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3′-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.

Solubility
Miscible with chloroform and dichloromethane.

Notes
Reacts violently with water. Incompatible with alcohols and strong bases.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 89992-70-1
Molecular Formula C9H18ClN2OP
Molecular Weight (g/mol) 236.68
MDL Number MFCD00011544
InChI Key QWTBDIBOOIAZEF-UHFFFAOYSA-N
Synonym 2-cyanoethyl n,n-diisopropylchlorophosphoramidite, 2-cyanoethyl-n,n-diisopropylchlorophosphoramidite, phosphoramidochloridous acid, bis 1-methylethyl-, 2-cyanoethyl ester, 2-cyanoethoxy diisopropylamino chlorophosphine, 3-chloro diisopropylamino phosphino oxy propanenitrile, 3-chloro-diisopropylamino phosphanyl oxypropanenitrile, 3-chloro diisopropylamino phosphanyl oxy propanenitrile, acmc-20anxd, 2-cyanoethyl diisopropylchloro-phosphoramidite, 2-cyanoethyl diisopropylphosphoramidochloridite
PubChem CID 2734844
IUPAC Name 3-[chloro-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
SMILES CC(C)N(C(C)C)P(OCCC#N)Cl

Specifications

Density 1.061
Boiling Point 103°C to 105°C (0.08 mmHg)
Flash Point >110°C (230°F)
Refractive Index 1.478
Quantity 1 g
UN Number UN2845
Beilstein 3588525
Sensitivity Moisture sensitive
Solubility Information Miscible with chloroform and dichloromethane.
Formula Weight 236.68
Percent Purity 95%
Chemical Name or Material 2-Cyanoethyl diisopropylchlorophosphoramidite
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Safety and Handling

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Product Identifier
  • 2-Cyanoethyl diisopropylchlorophosphoramidite
 Signal Word
  • Danger
 Hazard Category
  • Serious eye damage/eye irritation Category 1
  • Pyrophoric liquid Category 1
  • Skin corrosion/irritation Category 1 B
 Hazard Statement
  • H250-Catches fire spontaneously if exposed to air.
  • H314-Causes severe skin burns and eye damage.
  • H318-Causes serious eye damage.
 Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P231+P232-Handle under inert gas. Protect from moisture.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P334-IF ON SKIN: Immerse in cool water/wrap in wet bandages.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P402+P404-Store in a dry place. Store in a closed container.
 Supplemental information
  • MIXTURE LIST-Contains : 2-Cyanoethyl diisopropylchlorophosphoramidite
SDS

RUO – Research Use Only

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