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Thermo Scientific Chemicals Aldosterone, 98%

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

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Additional Details:
Additional Details: CAS Number: 52-39-1 Weight: 0.00010kg


Quantity 100 mg
Packaging Glass bottle

Disclaimers: RUO – Research Use Only

Product Code. 10195493

Quantity Price
1 1169.0  EUR / 100mg
Estimated Shipment
01-07-2026
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  • Description and Specification
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Description and Specification

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CAS 52-39-1
Molecular Formula C21H28O5
Molecular Weight (g/mol) 360.45
MDL Number MFCD00051136
InChI Key PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
PubChem CID 5839
ChEBI CHEBI:27584
IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O

Specification

Chemical Name or Material Aldosterone
Name Note 98%
CAS 52-39-1
CAS Min % 97.5
CAS Max % 100.0
Color White
Loss on Drying 6.0% max. (105°C, 3 hrs)
Infrared Spectrum Authentic
Assay Percent Range 98%
Packaging Glass bottle
Molecular Formula C21H28O5
MDL Number MFCD00051136
Quantity 100 mg
Beilstein 08, IV, 3491
Merck Index 15, 218
Specific Rotation Condition + 155.00 (20.00°C c=0.1,CHCl3)
Specific Rotation +150° to +162° (20°C, 589nm) (c=0.1, CHCl3)
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
Synonym aldosterone,electrocortin,aldocortin,aldocorten,aldocortene,+-aldosterone,elektrocortin,d-aldosterone,reichstein x,18-oxocorticosterone
InChI Key PQSUYGKTWSAVDQ-ZVIOFETBSA-N
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
Molecular Weight (g/mol) 360.45
PubChem CID 5839
ChEBI CHEBI:27584
Formula Weight 360.45
Percent Purity ≥97.5% (HPLC)
Physical Form Crystalline Powder

General Description

  • Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)
  • It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

  • Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure
  • In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes
  • Aldosterone has been used in combination with salt to induce renal injury in mice
  • It is used to stimulate primary liver sinusoidal endothelial cells

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