CAS RN 2304947-71-3

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TH5487, MedChemExpress

MedChemExpress TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.

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Specifications

Molecular Weight (g/mol)	541.18
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	TH5487
Grade	Research
SMILES	O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.23%
CAS	2304947-71-3
Solubility Information	DMSO : 25 mg/mL (46.20 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₈BrIN₄O₂
Formula Weight	541.18

CAS RN 2304947-71-3

CAS RN 2304947-71-3

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