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TH5487, MedChemExpress

Product Code. 16485238
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Product Code. 16485238 Supplier Medchem Express Supplier No. HY125276

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Description

MedChemExpress TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.

Specifications

Chemical Name or Material TH5487
CAS 2304947-71-3
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C19H18BrIN4O2
Quantity 10 mg
Solubility Information DMSO : 25 mg/mL (46.20 mM; Need ultrasonic)
SMILES O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4
Molecular Weight (g/mol) 541.18
Formula Weight 541.18
Percent Purity 99.23%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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