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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1

AZ PFKFB3 26, MedChemExpress

MedChemExpress AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 402.49
Color Yellow
Physical Form Solid
Chemical Name or Material AZ PFKFB3 26
Grade Research
SMILES O=C([C@H]1NCCC1)NC2=CC=C(OC3=CC4=C(N(CC(C)C)C=C4C#N)C=C3)C=C2
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.38%
CAS 1704740-52-2
Solubility Information DMSO : 5 mg/mL (12.42 mM; ultrasonic and adjust pH to 3 with HCl)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H26N4O2
Formula Weight 402.49
2

Indoximod, MedChemExpress

MedChemExpress Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer.

ENCOMPASS_PREFERRED
3

Trilaciclib hydrochloride, MedChemExpress

MedChemExpress Trilaciclib hydrochloride (G1T28 hydrochloride) is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 519.47
Color Yellow
Physical Form Solid
Chemical Name or Material Trilaciclib hydrochloride
Grade Research
SMILES O=C1C2=CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=N4)N=C3N2C6(CCCCC6)CN1.[H]Cl.[H]Cl
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.2%
CAS 1977495-97-8
Solubility Information H2O : 25.64 mg/mL (49.36 mM; ultrasonic and adjust pH to 2 with HCl) ∣DMSO : 1.1 mg/mL (2.12 mM; Need ultrasonic)
Synonym G1T28 hydrochloride
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C24H32Cl2N8O
Formula Weight 519.47