Pyrimidines And Derivatives

1 – 11 of 11 results

WYE-687, MedChemExpress

MedChemExpress WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	528.61
Color	Light Yellow
Physical Form	Powder
Chemical Name or Material	WYE-687
Grade	Research
SMILES	O=C(OC)NC1=CC=C(C2=NC(N3CCOCC3)=C4C(N(C5CCN(CC6=CC=CN=C6)CC5)N=C4)=N2)C=C1
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.1%
CAS	1062161-90-3
Solubility Information	DMSO : 20.83 mg/mL (39.41 mM; ultrasonic and warming and heat to 80°C)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₈H₃₂N₈O₃
Formula Weight	528.61

Reversan, MedChemExpress

MedChemExpress Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	441.52
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Reversan
Grade	Research
SMILES	O=C(C1=C2N(C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2)N=C1)NCCCN5CCOCC5
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	95.0%
CAS	313397-13-6
Solubility Information	DMSO : 15.62 mg/mL (35.38 mM; ultrasonic and warming and heat to 60°C)
Synonym	CBLC4H10
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₂₇N₅O₂
Formula Weight	441.52

Momelotinib, MedChemExpress

MedChemExpress Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	414.46
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Momelotinib
Grade	Research
SMILES	O=C(C1=CC=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)C=C1)NCC#N
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	96.95%
CAS	1056634-68-4
Solubility Information	DMSO : 20.83 mg/mL (50.26 mM; ultrasonic and warming and heat to 80°C)
Synonym	CYT387
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₂N₆O₂
Formula Weight	414.46

BAY 61-3606 dihydrochloride, MedChemExpress

MedChemExpress BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	463.32
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	BAY 61-3606 dihydrochloride
Grade	Research
SMILES	O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.21%
CAS	648903-57-5
Solubility Information	H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Purity Grade Notes	Research
Recommended Storage	-20°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	-20°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₀H₂₀Cl₂N₆O₃
Formula Weight	463.32

CU-CPT-8m, MedChemExpress

MedChemExpress CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	252.27
Color	White
Physical Form	Solid
Chemical Name or Material	CU-CPT-8m
Grade	Research
SMILES	O=C(C1=C2N=CC=C(C3=CC=CC(C)=C3)N2N=C1)N
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.81%
CAS	125079-83-6
Solubility Information	DMSO : 12.5 mg/mL (49.55 mM; ultrasonic and warming and heat to 60°C)
Health Hazard 1	H302∣H315∣H319∣H335
Synonym	TLR8-specific antagonist
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₄H₁₂N₄O
Formula Weight	252.27

Pictilisib, MedChemExpress

MedChemExpress Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	513.64
Color	Off-White
Physical Form	Solid
Chemical Name or Material	Pictilisib
Grade	Research
SMILES	CS(N1CCN(CC2=CC3=C(C(N4CCOCC4)=NC(C5=CC=CC6=C5C=NN6)=N3)S2)CC1)(=O)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.03%
CAS	957054-30-7
Solubility Information	DMSO : 100 mg/mL (194.69 mM; ultrasonic and warming and heat to 60°C)
Synonym	GDC-0941
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₃H₂₇N₇O₃S₂
Formula Weight	513.64

PI-103 Hydrochloride, MedChemExpress

MedChemExpress PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	384.82
Color	Yellow
Physical Form	Solid
Chemical Name or Material	PI-103 Hydrochloride
Grade	Research
SMILES	OC1=CC(C2=NC3=C(OC4=C3C=CC=N4)C(N5CCOCC5)=N2)=CC=C1.[H]Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	96.37%
CAS	371935-79-4
Solubility Information	DMSO : 4.1 mg/mL (10.65 mM; Need ultrasonic and warming) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₉H₁₇ClN₄O₃
Formula Weight	384.82

GNF-2, MedChemExpress

MedChemExpress GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM .

Pricing and Availability
Specifications

Molecular Weight (g/mol)	374.32
Color	White
Physical Form	Solid
Chemical Name or Material	GNF-2
Grade	Research
SMILES	O=C(C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)N
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.73%
CAS	778270-11-4
Solubility Information	DMSO : ≥ 100 mg/mL (267.15 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₃F₃N₄O₂
Formula Weight	374.32

SSD114 hydrochloride, MedChemExpress

MedChemExpress SSD114 hydrochloride is a novel GABAB receptor positive allosteric modulator.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	387.83
Color	White
Physical Form	Solid
Chemical Name or Material	SSD114 hydrochloride
Grade	Research
SMILES	FC(C1=CC=C(C2=CC(OC)=NC(NC3CCCCC3)=N2)C=C1)(F)F.[H]Cl
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.68%
CAS	2319790-02-6
Solubility Information	DMSO : 130 mg/mL (335.20 mM; Need ultrasonic) ∣H2O : 2 mg/mL (5.16 mM; ultrasonic and warming and heat to 60°C)
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₈H₂₁ClF₃N₃O
Formula Weight	387.83

CRT0066101 dihydrochloride, MedChemExpress

MedChemExpress CRT0066101 dihydrochloride is a potent and specific PKD inhibitor with IC50 values of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	411.33
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	CRT0066101 dihydrochloride
Grade	Research
SMILES	OC1=CC=C(C2=CN(C)N=C2)C=C1C3=NC=CC(NC[C@H](N)CC)=N3.[H]Cl.[H]Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.53%
CAS	1883545-60-5
Solubility Information	H2O : 50 mg/mL (121.56 mM; Need ultrasonic) ∣DMSO : 11.36 mg/mL (27.62 mM; ultrasonic and warming and heat to 60°C)
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₁₈H₂₄Cl₂N₆O
Formula Weight	411.33

Dorsomorphin, MedChemExpress

MedChemExpress Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	399.49
Color	Yellow
Physical Form	Solid
Chemical Name or Material	Dorsomorphin
Grade	Research
SMILES	C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.0%
CAS	866405-64-3
Solubility Information	1M HCl : 50 mg/mL (125.16 mM; ultrasonic and adjust pH to 1 with HCl) ∣DMSO : 5 mg/mL (12.52 mM; ultrasonic and warming and heat to 60°C) ∣Ethanol : 3.33 mg/mL (8.34 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
Synonym	Compound C BML-275
Purity Grade Notes	Research
Recommended Storage	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Shelf Life	4°C, protect from light∣In solvent : -80°C, 6 months∣-20°C, 1 month (protect from light)
Molecular Formula	C₂₄H₂₅N₅O
Formula Weight	399.49

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