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Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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1 – 15 of 113 results
1

PROTAC BET Degrader-1, MedChemExpress

MedChemExpress PROTAC BET Degrader-1 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 871.9
Color Yellow
Physical Form Solid
Chemical Name or Material PROTAC BET Degrader-1
Grade Research
SMILES CCN1C(NC2=C3C4=CC(OC)=C(C(C(C)=NO5)=C5C)C=C4NC3=NC(C(NCCCCNC(COC6=C(C(N7C(CCC8=O)C(N8)=O)=O)C(C7=O)=CC=C6)=O)=O)=N2)=CC(C9CC9)=N1
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.01%
CAS 2093386-22-0
Solubility Information DMSO : ≥ 50 mg/mL (57.35 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C44H45N11O9
Formula Weight 871.9
2

AF64394, MedChemExpress

MedChemExpress AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 393.87
Color White
Physical Form Solid
Chemical Name or Material AF64394
Grade Research
SMILES ClC1=CC(OC(C)C)=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C=C1
Percent Purity 98.02%
CAS 1637300-25-4
Solubility Information DMSO : ≥ 125 mg/mL (317.36 mM)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H20ClN5O
Formula Weight 393.87
3

Laduviglusib monohydrochloride, MedChemExpress

MedChemExpress Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 501.8
Color Light Yellow
Physical Form Solid
Chemical Name or Material Laduviglusib monohydrochloride
Grade Research
SMILES N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.36%
CAS 1797989-42-4
Solubility Information DMSO : 60 mg/mL (119.57 mM; Need ultrasonic) ∣H2O : 7.14 mg/mL (14.23 mM; Need ultrasonic)
Synonym CHIR-99021 monohydrochlorideCT99021 monohydrochloride
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C22H19Cl3N8
Formula Weight 501.8
4

Lck Inhibitor, MedChemExpress

MedChemExpress Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 530.62
Color Yellow
Physical Form Solid
Chemical Name or Material Lck Inhibitor
Grade Research
SMILES O=C1N(C2=C(C)C=CC=C2C)C3=NC4=CC=CC=C4N3C5=NC(NC6=CC=C(N7CCN(C)CC7)C=C6)=NC=C15
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.2%
CAS 847950-09-8
Solubility Information DMSO : 100 mg/mL (188.46 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C31H30N8O
Formula Weight 530.62
5

UNC2881, MedChemExpress

MedChemExpress UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 463.58
Color Off-White
Physical Form Solid
Chemical Name or Material UNC2881
Grade Research
SMILES CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.91%
CAS 1493764-08-1
Solubility Information DMSO : ≥ 44 mg/mL (94.91 mM)
Health Hazard 1 H302
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H33N7O2
Formula Weight 463.58
6

GDC-0349, MedChemExpress

MedChemExpress GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 452.55
Color Yellow
Physical Form Solid
Chemical Name or Material GDC-0349
Grade Research
SMILES O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.0%
CAS 1207360-89-1
Solubility Information DMSO : ≥ 100 mg/mL (220.97 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H32N6O3
Formula Weight 452.55
7

Pyrimethamine, MedChemExpress

MedChemExpress Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 248.71
Color White
Physical Form Solid
Chemical Name or Material Pyrimethamine
Grade Research
SMILES NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
For Use With (Application) COVID-19-anti-virus
Percent Purity 99.9%
CAS 58-14-0
Solubility Information DMSO : 20 mg/mL (80.41 mM; Need ultrasonic)
Health Hazard 1 H302
Synonym Pirimecidan Pirimetamin RP 4753
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C12H13ClN4
Formula Weight 248.71
8

PF-4840154, MedChemExpress

MedChemExpress PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 466.62
Color Off-White
Physical Form Solid
Chemical Name or Material PF-4840154
Grade Research
SMILES O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.0%
CAS 1332708-14-1
Solubility Information DMSO : 50 mg/mL (107.15 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H38N6O2
Formula Weight 466.62
9

ALLO-2, MedChemExpress

MedChemExpress ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 371.32
Color Yellow
Physical Form Solid
Chemical Name or Material ALLO-2
Grade Research
SMILES FC(F)(OC1=CC=C(C=C1)C2=NC(NC3=CC4=C(C=C3)NN=C4)=NC=C2)F
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.58%
CAS 1357350-60-7
Solubility Information DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C18H12F3N5O
Formula Weight 371.32
10

NIH-12848, MedChemExpress

MedChemExpress NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 385.41
Color White
Physical Form Solid
Chemical Name or Material NIH-12848
Grade Research
SMILES FC(C1=CC=CC=C1C2=NC(NCC3=CC=CS3)=C4C=CC=CC4=N2)(F)F
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.06%
CAS 959551-10-1
Solubility Information DMSO : ≥ 100 mg/mL (259.46 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H14F3N3S
Formula Weight 385.41
11

KDM4D-IN-1, MedChemExpress

MedChemExpress KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 225.21
Color Earth Yellow
Physical Form Solid
Chemical Name or Material KDM4D-IN-1
Grade Research
SMILES OC1=NC2=C(C#N)C(C)=NN2C3=C1C=CC=N3
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.91%
CAS 2098902-68-0
Solubility Information DMSO : 7.14 mg/mL (31.70 mM; Need ultrasonic)
Health Hazard 1 H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C11H7N5O
Formula Weight 225.21
12

EPZ015666, MedChemExpress

MedChemExpress EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 383.44
Color White
Physical Form Solid
Chemical Name or Material EPZ015666
Grade Research
SMILES O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.96%
CAS 1616391-65-1
Solubility Information DMSO : 100 mg/mL (260.80 mM; Need ultrasonic)
Synonym GSK3235025
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H25N5O3
Formula Weight 383.44
13

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 474.56
Color White
Physical Form Solid
Chemical Name or Material mTOR inhibitor-3
Grade Research
SMILES O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.58%
CAS 1207358-59-5
Solubility Information DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H30N8O2
Formula Weight 474.56
14

DMH-1, MedChemExpress

MedChemExpress DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 380.44
Color Yellow
Physical Form Solid
Chemical Name or Material DMH-1
Grade Research
SMILES CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.58%
CAS 1206711-16-1
Solubility Information DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H20N4O
Formula Weight 380.44
15

Citarinostat, MedChemExpress

MedChemExpress Citarinostat (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). Citarinostat has anticancer effects.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 467.95
Color White
Physical Form Solid
Chemical Name or Material Citarinostat
Grade Research
SMILES O=C(C1=CN=C(N(C2=CC=CC=C2Cl)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 95.0%
CAS 1316215-12-9
Solubility Information DMSO : ≥ 30 mg/mL (64.11 mM)
Synonym ACY241
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C24H26ClN5O3
Formula Weight 467.95