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  7. Laduviglusib monohydrochloride, MedChemExpress

Laduviglusib monohydrochloride, MedChemExpress

Product Code. 16406327
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Product Code. 16406327 Supplier Medchem Express Supplier No. HY10182A

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Description

MedChemExpress Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM.

Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.

Specifications

Chemical Name or Material Laduviglusib monohydrochloride
CAS 1797989-42-4
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C22H19Cl3N8
Quantity 5 mg
Synonym CHIR-99021 monohydrochlorideCT99021 monohydrochloride
Solubility Information DMSO : 60 mg/mL (119.57 mM; Need ultrasonic) ∣H2O : 7.14 mg/mL (14.23 mM; Need ultrasonic)
SMILES N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
Molecular Weight (g/mol) 501.8
Formula Weight 501.8
Percent Purity 98.36%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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