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Tocris Bioscience™ Zosuquidar Trihydrochloride
High affinity P-gp inhibitor
Brand: Tocris Bioscience™ 5456/10
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Description
Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.Specifications
| Zosuquidar trihydrochloride | |
| (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride | |
| Soluble to 50mM in DMSO | |
| Bioactive Small Molecule |
| 167465-36-3 | |
| 10 mg | |
| Solid |
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