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  5. Tocris Bioscience™ EN 219

Tocris Bioscience™ EN 219
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Product Code. 18758366
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 18758366

Brand: Tocris Bioscience™ 7476/25

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This item is not returnable. View return policy

Description

Covalent RNF114 ligand

EN 219 is a covalent RNF114 inhibitor (IC50 = 470 nM). In vitro EN 219 mimics the mechanism of action of Nimbolide (Cat. No. 7289) by binding to RNF114 and inhibiting ubiquitination of its endogenous substrate, the tumor suppressor p21.
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Specifications

Chemical Name or Material 1-[3,5-bis(4-Bromophenyl)-4,5-dihydro-1 H-pyrazol-1-yl]-2-chloroethanone
CAS 380351-29-1
Quantity 25 mg
Target RNF114
Molecular Formula C17H13Br2ClN2O
Purity 0.98
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