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Topotecan hydrochloride, Tocris Bioscience™

Catalog Number 18772544
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
119413-54-6
C23H23N3O5
421.45
MFCD28989044
UCFGDBYHRUNTLO-QHCPKHFHSA-N
topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
60699
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O
This item is not returnable. View return policy
119413-54-6
C23H23N3O5
421.45
MFCD28989044
UCFGDBYHRUNTLO-QHCPKHFHSA-N
topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
60699
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O

Description

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
Quantity 10 mg
Formula Weight 457.91
Percent Purity >98%
Chemical Name or Material Topotecan hydrochloride
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