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  5. Tocris Bioscience™ TH 1760

Tocris Bioscience™ TH 1760
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Product Code. 18785745
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Product Code. 18785745 Supplier Tocris Bioscience™ Supplier No. 7422/50

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Description

Potent and selective NUDT15 hydrolase inhibitor

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.
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Specifications

Chemical Name or Material 6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
CAS 2567914-01-4
Quantity 50 mg
Target Hydrolase Inhibitors
Molecular Formula C20H18N4O5S
Purity 0.95
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