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  5. Tocris Bioscience™ TASP 0433864

Tocris Bioscience™ TASP 0433864
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Product Code. 18741068
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Product Code. 18741068 Supplier Tocris Bioscience™ Supplier No. 5362/10

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164.00 EUR valid until 2026-03-31
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Description

Selective mGlu2 receptor positive allosteric modulator

TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
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Specifications

Chemical Name or Material (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
CAS 1431980-60-7
Synonym mGlu2 receptor positive allosteric modulator
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Molecular Formula C18H23N3O3
Formula Weight 329.39
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%
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