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T025, MedChemExpress

Product Code. 16477327
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Quantity:
5 mg
Unit Size:
5mg
Product Code. Quantity unitSize
16477327 5 mg 5mg
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Product Code. 16477327

Brand: Medchem Express HY112296

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Description

MedChemExpress T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively.

T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research.

Specifications

Chemical Name or Material T025
Physical Form Solid
CAS 2407433-00-3
Color Yellow
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C21H18N8
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : 8.25 mg/mL (21.57 mM; Need ultrasonic)
SMILES CNC1=NC(NCC2=NC=CC=N2)=C(C(C3=CC=C(N=CC=C4)C4=C3)=CN5)C5=N1
Molecular Weight (g/mol) 382.42
Formula Weight 382.42
Percent Purity 98.01%
Grade Research
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Research purposes only

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