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SR 202, Tocris Bioscience™
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Product Code. 18055382
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18055382 10 mg 10mg
18045262 50 mg 50mg
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Product Code. 18055382 Supplier Tocris Bioscience Supplier No. 2022/10

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Description

Selective PPARγ antagonist; antidiabetic and antiobesity agent

Selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 76541-72-5
Molecular Formula C11H17ClO7P2
Molecular Weight (g/mol) 358.648
InChI Key VQHUQHAPWMNBLP-UHFFFAOYSA-N
Synonym mifobate, clenicor, mifobatum latin, mifobato spanish, mifobate usan:inn, 4-chlorophenyl dimethoxyphosphinyl methyl phosphoric acid dimethyl ester, dimethyl alpha-dimethoxyphosphinyl-p-chlorobenzyl phosphate, dimethyl p-chloro-alpha-hydroxybenzyl phosphonate, dimethyl phosphate, phosphoric acid, 4-chlorophenyl dimethoxyphosphinyl methyl dimethyl ester, dsstox_cid_25741
PubChem CID 60910
IUPAC Name [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl phosphate
SMILES COP(=O)(C(C1=CC=C(C=C1)Cl)OP(=O)(OC)OC)OC

Specifications

Quantity 10 mg
Formula Weight 358.65
Percent Purity >99%
Chemical Name or Material SR 202
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