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  5. Tocris Bioscience™ SCH 51344

Tocris Bioscience™ SCH 51344
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Product Code. 18702168
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18702168 10 mg 10mg
18794519 50 mg 50mg
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Product Code. 18702168

Brand: Tocris Bioscience™ 5280/10

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Description

Potent MTH1 inhibitor

SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.
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Specifications

Purity >99%
Quantity 10 mg
Product Type SCH 51344
Molecular Weight (g/mol) 316.35
Inhibitors SCH 51344

For Research Use Only

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