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Ripretinib, MedChemExpress

Product Code. 16464618
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Product Code. 16464618 Supplier Medchem Express Supplier No. HY112306

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Description

MedChemExpress Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor.

Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2). DCC-2618 exerts antineoplastic effect and induces apoptosis.

Specifications

Chemical Name or Material Ripretinib
CAS 1442472-39-0
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C24H21BrFN5O2
Quantity 10 mg
Synonym DCC-2618
Solubility Information DMSO : 25 mg/mL (48.99 mM; Need ultrasonic)
SMILES O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4
Molecular Weight (g/mol) 510.36
Formula Weight 510.36
Percent Purity 98.05%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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