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TOKU-E™ Rifampicin ReadyMade™ Solution

Product Code. 30044020
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100 mL
Unit Size:
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Product Code. 30044020 Supplier TOKU-E™ Supplier No. R041100ML

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Description

Rifampicin ReadyMade™ Solution is provided as a sterile-filtered solution of Rifampicin in water.

  • CAS Number: 13292-46-1
  • Molecular Formula: C43H58N4O12
  • Molecular Weight: 822.94 g/mol
  • Storage Conditions: -20°C, Protect from light
  • Form: Liquid (in water with starch as a solubilizer)
  • Source: Semi-synthetic - Amycolatopsis rifamycinica
  • Spectrum: Rifampicin is a broad-spectrum antibiotic with a wide range of activity including: Gram-positive aerobic bacteria, particularly Staphylococcus spp and Rhodococcus equ. Brucella and some other fastidious organisms are susceptible but Gram-negative bacteria more generally are resistant; Gram-positive and Gram-negative anaerobic bacteria at low concentrations, including Bacteroides fragilis, Chlamydophila and Rickettsia; Mycobacterium tuberculosis (note: most other mycobacteria are resistant); some protozoa; some fungi; and poxviruses
  • Mechanism of Action: Rifampicin targets prokaryotic DNA-dependent RNA polymerases which prevent subsequent RNA transcription and protein translation. Bacterial resistance to Rifampicin is caused by mutations leading to a change in the structure of the β-subunit of RNA polymerase. Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to the β-subunit of RNA polymerase, which results in cell death. Rifampicin has been shown to inhibit α-synuclein fibrillation and disaggregate fibrils in a concentration-dependent manner. Rifampicin can activate pregnane X receptor (PXR), which affects cytochrome P450, and the activity of glucuronosyltransferases and P-glycoprotein. Rifampicin has been shown to enhance CYP2C-mediated metabolism, affecting compounds that are transported by P-glycoprotein and metabolized by CYP3A4

Specifications

CAS 13292-46-1
Chemical Name or Material Rifampicin
Color Red
Content And Storage -20°C, Protect from light
Description Rifampicin ReadyMade™ Solution 10 g/mL in Water
Concentration 8 to 12 mg/mL
Form Liquid
Product Type Antibiotic
Sterility Sterile
Sterilization Method Sterile-filtered
With Additives None
Without Additives None
Formulation Liquid in Water
For Use With (Application) Microbiology, Plant Biology and Eukaryotic Cell Culture Applications
Product Line ReadyMade™ Solutions
Purity or Quality Grade >90%
Quantity 100 mL
Shipping Condition Ice Pack
Source Semi-synthetic
Species Bacteria
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