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BD Biosciences™ Regulatory T-Cell Function Kit (RUO/GMP)

Product Code. 15876319
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Quantity:
50 Tests
Unit Size:
1 set
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15876319 50 Tests 1 set
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Product Code. 15876319 Supplier BD Biosciences™ Supplier No. 648956

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Description

Measures expression of the activation markers CD154 and/or CD69 on effector T cells.

  • Naturally occurring human CD4+ regulatory T cells (Tregs) are critical mediators of self-tolerance and suppress aberrant or inappropriate immune responses that can lead to conditions such as type 1 diabetes, rheumatoid arthritis, and graft-vs-host disease.
  • The BD FastImmune™ kit measures expression of the activation markers CD154 and/or CD69 on effector T cells.
  • Reduced expression of these markers in the presence of Tregs can indicate Treg suppressive capacity.
  • The assay is performed in 96-well microplates using peripheral blood mononuclear cells (PBMCs) activated in the presence and absence of Tregs.
  • It is a short-term assay that can be set up and analyzed in approximately one day.
  • The T-cell markers, CD3 and CD4, are included in the kit for T-cell gating purposes, and CD25 is included for defining the Treg population.
  • Contents: Regulatory T-Cell function cocktail (CD3 PerCP-Cy™5.5, CD4 FITC, CD25 PE); CD69 PE-Cy™7; CD154 APC; EDTA.
TRUSTED_SUSTAINABILITY

Specifications

For Use With (Equipment) Flow cytometer
Formulation CD154, APC, CD4 FITC/CD25 PE/CD3 PerCP-CY 5.5, CD69, PE-CY7, EDTA
Includes CD154, APC, CD4 FITC/CD25 PE/CD3 PerCP-CY 5.5, CD69, PE-CY7, EDTA
Quantity 50 Tests
Regulatory Status RUO/GMP
Content And Storage Store reagents at 2°C to 8°C. Conjugated forms should not be frozen and should be protected from exposure to light.
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