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Rapamycin, 98+%

Product Code. 15434849
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100 mg
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Produktkod. 15434849 Leverantör Thermo Scientific Alfa Aesar Leverantörsnummer J62473.MC
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Beskrivning

Rapamycin, CAS # 53123-88-9, is a macrolide compound showing suppressor activity against the immune system and also exhibits inhibitory activity in tumor growth. | CAS: 53123-88-9 | C51H79NO13 | 914.187 g/mol

Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
  • Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)

Application

  • Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
  • This compound also blocks cytokine-mediated signal transduction pathways
  • Rapamycin also promotes the suppression of the immune system
  • It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
  • In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 53123-88-9
Molecular Formula C51H79NO13
Molecular Weight (g/mol) 914.187
MDL Number MFCD00867594
InChI Key QFJCIRLUMZQUOT-HPLJOQBZSA-N
Synonym Sirolimus; AY-22989
PubChem CID 5284616
ChEBI CHEBI:9168
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

Specifikationer

Type Rapamycin
Physical Form Powder
Color White
Quantity 100 mg
Merck Index 14,8114
Solubility Information Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in water.
Formula Weight 914.17
Percent Purity ≥99%
Chemical Name or Material Rapamycin

RUO – Research Use Only

Produkttitel
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