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ARRB1 (phospho S412), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Product Code. 16274250
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Quantity:
100 μL
Unit Size:
100µL
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16274250 100 μL 100µL
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Product Code. 16274250 Supplier Abnova Supplier No. PAB29259.100uL

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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ARRB1.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq

Specifications

Antigen ARRB1
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ARRB1.
Dilution Immunohistochemistry (1:50∼1:100) Western Blot (1:500∼1:1000) The optimal working dilution should be determined by the end user.
Formulation In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene ARRB1
Gene Accession No. P49407
Gene Alias ARB1/ARR1
Gene Symbols ARRB1
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S412 of human ARRB1.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 408
Test Specificity ARRB1 (phospho S412) polyclonal antibody detects endogenous levels of human ARRB1 only when phosphorylated at serine 412.
Target Species Human, Mouse
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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