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  6. Puromycin dihydrochloride, 98%

Puromycin dihydrochloride, 98%

Product Code. 15493889
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Product Code. 15493889 Supplier Thermo Scientific Alfa Aesar Supplier No. J61278.MC
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    252.65 EUR / 100mg
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Beskrivelse

Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis. | CAS: 58-58-2 | C22H31Cl2N7O5 | 544.43 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General Information

• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis

Applications

• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.

TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 58-58-2
Molecular Formula C22H31Cl2N7O5
Molecular Weight (g/mol) 544.43
MDL Number MFCD00150080
InChI Key MKSVFGKWZLUTTO-MLYJQVMKNA-N
PubChem CID 131632508
SMILES Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

Tekniske data

Type Puromycin Dihydrochloride
Physical Form Powder
Melting Point 168°C to 170°C
Color White
Quantity 100 mg
Beilstein 3853613
Merck Index 14,7943
Solubility Information Soluble in water
IUPAC Name (2S)-2-amino-N-[(2S,3S,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
Formula Weight 544.44
Percent Purity 99%
Chemical Name or Material Puromycin dihydrochloride
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Sikkerhed og håndtering

compliance-icons
Produktidentifikator
  • Puromycin dihydrochloride
 Signalord
  • Warning
 Farekategori
  • Acute toxicity Category 4
 Faresætning
  • H302-Harmful if swallowed.
 Sikkerhedssætning
  • P264-Wash face, hands, and anyexposed skin thoroughly after handling.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplerende oplysninger
  • MIXTURE LIST-Contain: (S)-3-[[2-Amino-3-(4-methoxyphenyl)-1-oxo propyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochlorid
SDS

RUO – Research Use Only

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