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  6. STEMCELL Technologies Puromycin (Dihydrochloride)

STEMCELL Technologies Puromycin (Dihydrochloride)

Product Code. 17110212
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500 mg
Unit Size:
500mg
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Product Code. Quantity unitSize
17110212 500 mg 500mg
17100212 50 mg 50mg
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Product Code. 17110212

Brand: STEMCELL Technologies 73344

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Description

Antibiotic; Protein synthesis inhibitor

  • Puromycin is an aminonucleoside antibiotic, derived from Streptomyces alboniger, which acts as a protein synthesis inhibitor
  • It binds to the target ribosome site A, where it is transferred to the growing polypeptide chain causing premature chain termination (Lührmann et al.; Rodriguez-Fonseca et al.; Azzam & Algranati)
  • A biologically inactive form is generated when puromycin is N-acetylated by puromycin-N-acetyltransferase, allowing this gene to be used as a selective resistance marker (Vara et al.) 1985)
  • Selects for cells expressing puromycin-N-acetyltransferase resistance gene as a research tool (de la Luna & Ortín; Iwaki et al.)
  • Useful in CRISPR/Cas9 mammalian gene editing by selecting for successful Cas9-induced knock-in with puromycin resistance gene (Park et al.)
  • Possesses anti-tumor activity when tested against numerous cell lines (Foley & Eagle)

Specifications

CAS 58-58-2
Quantity 500 mg
Percent Purity ≥98%
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