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Tocris Bioscience™ PSEM 89S
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Product Code. 18769406
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25 mg
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18769406 25 mg 25mg
18798736 5 mg 5mg
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Product Code. 18769406 Supplier Tocris Bioscience™ Supplier No. 6426/25

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Description

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

PSEM 89S is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

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Specifications

Chemical Name or Material N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
CAS 1336913-03-1
Quantity 25 mg
Target Pharmacologically Selective Effector Molecules/PSEM
Molecular Formula C16H22N2O3.CF3CO2H
Formula Weight 404.38
Purity 98%
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