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Invitrogen™ Phospho-SRPK2 (Thr492) Polyclonal Antibody
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Product Code. 17217413 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17217413 100 μL 100µL
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Product Code. 17217413 Supplier Invitrogen™ Supplier No. PA5114646

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SRPK2 only when phosphorylated at Thr492.

SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It therefore represents an important host cell target for therapeutic intervention in HBV infection. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles .
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SRPK2 (Thr492)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene SRPK2
Gene Accession No. O54781, P78362
Gene Alias AW226533; AW492537; AW547358; H_RG152G17.1a; H_RG152G17.1b; mSRPK2; serine kinase SRPK2; serine/arginine-rich protein specific kinase 2; serine/arginine-rich protein-specific kinase 2; serine/arginine-rich splicing factor kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SFRSK2; SR protein kinase 2; SRPK2; SR-protein-specific kinase 2; SRSF protein kinase 2; SRSF protein kinase 2 C-terminal; SRSF protein kinase 2 N-terminal; Wbp6; WUGSC:H_RG152G17.1a; WW domain binding protein 6
Gene Symbols SRPK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SRPK2 around the phosphorylation site of Thr492.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20817, 6733
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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