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Invitrogen™ PPARGC1A Polyclonal Antibody

Product Code. 15967840
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100 μL
Unit Size:
1mL
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15967840 100 μL 1mL
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Product Code. 15967840 Supplier Invitrogen™ Supplier No. PA572948
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Description

Rabbit Polyclonal Antibody

Expected from sequence similarity: Mouse. In IHC-P, staining is very strong in the nucleus with some cytoplasmic staining. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PPARGC1A
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Ppargc1a
Gene Accession No. O70343, Q865B6, Q9QYK2, Q9UBK2
Gene Alias A830037N07Rik; ENSMUSG00000079510; Gm11133; I79_015506; LEM6; Ligand effect modulator 6; ligand effect modulator-6; L-PGC-1alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Pgc1; PGC-1; pgc-1 alpha; PGC-1(alpha); PGC1A; PGC-1alpha; PGC-1-alpha; Pgc-1alphaa; PGC-1v; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPARG coactivator 1 alpha; PPARgamma coactivator 1alpha; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC1A; PPARGC-1-alpha
Gene Symbols Ppargc1a
Host Species Rabbit
Immunogen Recombinant protein made to an internal portion of the human PGC-1 alpha protein (within residues 400-550).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100753651, 100861288, 10891, 19017, 397013, 443270, 479127, 83516
Target Species Human, Mouse, Rat, Canine, Sheep, Hamster, Pig, Rodent, Goat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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