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DiscoverX PathHunter™ eXpress XBP1 Nuclear Translocation Assay

Product Code. 17333909
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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17333909 1,000 dp (10 x 96-well) 1 set
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Product Code. 17333909 Supplier DiscoverX Supplier No. 930857E3CP5L

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Description

The PathHunter™ eXpress XBP1 Nuclear Translocation Assay measures IRE1-XBP1 pathway activation via nuclear translocation of XBP1. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ eXpress XBP1 Nuclear Translocation Assay provides an easy-to-use cell based assay to study drug candidates affecting the IRE1/XBP1 pathway. This kit assesses ligand (e.g. thapsigargin) based pathway activation via detection of resulting XBP1 nuclear translocation. This product uses EFC technology. The included cells overexpress PL-tagged XBP1 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of XBP1 leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Translocation
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Thapsigargin
Quantity 1,000 dp (10 x 96-well)
Target Entry XBP1
Cell Line U2OS
Target XBP1
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