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DiscoverX PathHunter™ eXpress TrkB Functional Assay

Product Code. 17363209
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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Product Code. Quantity unitSize
17363209 1,000 dp (10 x 96-well) 1 set
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Product Code. 17363209 Brand DiscoverX Brand No. 930463E3CP16L

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Description

The PathHunter™ eXpress TrkB Functional Assay measures TrkB receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ eXpress TrkB Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkB dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged TrkB and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Kinase
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry TrkB
Target TrkB
Product Title
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