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DiscoverX PathHunter™ eXpress GHR-JAK1 Functional Assay

Product Code. 17333769
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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17333769 1,000 dp (10 x 96-well) 1 set
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Product Code. 17333769 Supplier DiscoverX Supplier No. 930756E3CP0L

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Description

The PathHunter™ eXpress GHR-JAK1 Functional Assay measures GHR cytokine receptor activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ GHR-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses GHR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged GHR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Kinase
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry GHR-JAK1
Target GHR-JAK1
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