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DiscoverX PathHunter™ eXpress c-KIT Functional Assay

Product Code. 17303909
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Quantity:
200 dp (2 x 96-well)
Unit Size:
1 set
Product Code. Quantity unitSize
17303909 200 dp (2 x 96-well) 1 set
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Product Code. 17303909

Brand: DiscoverX 930853E3CP16M

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress c-KIT Functional Assay measures c-KIT receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates. Cyno version.

The PathHunter™ eXpress c-KIT Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-KIT dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged c-KIT and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Cyno version of the protein.

Specifications

Assay Entry Receptor Phosphorylation
For Use With (Application) Assay-Ready eXpress Kits
Format 200 dp (2 x 96-well)
Primary Agonist Recombinant Human SCF
Quantity 200 dp (2 x 96-well)
Target Entry c-KIT
Cell Line U2OS
Target c-KIT
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